The son of Peruvian jockey Jose Mena, brother of jockey Alderly Mena, and nephew of a trainer, Miguel Mena came to America to follow in the footsteps of fellow Peruvians Edgar Prado and Rafael Bejarano. After attending jockey school at age 12 and riding in Peru, he moved to Florida in 2004 at the age of 18. A move to the Midwest and eventually Kentucky followed as his star rose, and riding titles at Ellis Park and Turfway Park in 2006, and Presque Isle Downs in 2007 led eventually to riding for Hall of Fame trainer D. Wayne Lukas in the 2009 Belmont Stakes on Luv Gov.
Recovering from problems with alcohol in recent years, and now paired with a new agent, Fred Aime, Mena rides at Fair Grounds in the winter, and Kentucky and Saratoga Race Course the rest of the year. He won his first Grade 1 in 2010 aboard Champagne d’Oro in the Test Stakes, and finished third in the standings at Fair Grounds for the 2011-12 season.
In 2015, Mena swept the Grade 3 Lecomte Stakes, the Grade 2 Risen Star Stakes and and the Louisiana Derby with International Star. He also reached the 1,500-career win plateau.