Pletcher was groomed for the success he has found since opening his own stable with seven horses in 1995. The son of trainer Jake Pletcher, he graduated from the University of Arizona Race Track Industry Program with a degree in Animal Science. While a student, he spent his summers working for prominent trainers Henry Moreno, Charlie Whittingham and D. Wayne Lukas. Two weeks after graduating, he went to work for Lukas, where he spent seven years before going out on his own. Within a few years, Pletcher had emerged as one of the world's foremost trainers. He oversees a vast operation of some 200 horses with divisions at the nation's leading tracks.
He has developed 10 champions: Uncle Mo, Rags to Riches, Lawyer Ron, English Channel, Wait a While, Fleet Indian, Speightstown, Ashado (twice), Shanghai Bobby, and Left Bank. He won his first Triple Crown race in 2007 when the filly Rags to Riches edged Curlin in the Belmont Stakes and earned his first Kentucky Derby victory with Super Saver in 2010. Pletcher has won the Eclipse Award as the outstanding trainer six times. He earned his 3,000th victory on Feb. 11, 2012 when Spring Hill Farm won the third race at Gulfstream Park.
In 2013, Pletcher was represented by five colts in the Kentucky Derby, easily the most of any trainer to run a horse in the race. He also sent five fillies to the Kentucky Oaks, nearly half the field. After letting his fleet sit out the Preakness, Pletcher saddled five horses for the Belmont Stakes including the only filly in the field, Unlimited Budget. The move proved to be a wise one as he ended up in the Belmont winner's circle with Palace Malice.
At the end of the year, Pletcher set a record when he earned his sixth career Eclipse Award as outstanding trainer after his trainees earned more that $25.2 million in earnings and 48 graded stakes including the Kentucky Oaks and Belmont Stakes.
In 2014, Pletcher continued his dominance in the sport by leading all trainers by purse earnings, graded stakes wins and stakes wins. He secured his record seventh career Eclipse Award as outstanding trainer.